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maninialex.bsky.social
Manini AF
@maninialex.bsky.social
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Professor @MountSinaiNYC, views my own. Director and Founder of Mount Sinai RESPOND Center. https://icahn.mssm.edu/about/departments/emergency-medicine/research/respond-center See more https://youtu.be/NJpBa3tDVB4
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Exciting news: Our team has been awarded a NIDA R01 grant to fund "Fentalog II", a continuation of our groundbreaking collaboration to detect novel fentanyl analogue overdoses in EDs across ten major hospitals over five years. #syntheticopioids
#Medsky 🧵
www.mountsinai.org/about/newsro...
Mount Sinai Receives $3.8 Million Grant to Study New Synthetic Drugs and Opioid Overdoses in Emergency Departments to Prevent Deaths
www.mountsinai.org
5/ Bottom line: fentanyl still rules, but the “other stuff” — novel benzos, veterinary sedatives, synthetic cannabinoids — is the stealthy threat changing overdose care. Full report: npsdiscovery.org #DrugTrends
NPS Discovery
npsdiscovery.org
4/ Clinically, this underscores why standard opioid panels miss the mark. LC-QTOF-MS detected >1,200 substances, catching dangerous adulterants missed by routine screens. Treatment must anticipate multi-drug toxicity. #EmergencyMedicine
www.cdc.gov/overdose-pre...
The Fentalog Study: A Subset of Nonfatal Suspected Opioid-Involved Overdoses with Toxicology Testing
View substances detected in samples from patients experiencing a suspected opioid-involved overdose.
www.cdc.gov
3/ Public health takeaway: street drugs are increasingly poly-drug cocktails. Testing found opioids + stimulants + sedatives in the same patient; this complicates outreach, naloxone use, and treatment planning. #OverdosePrevention
1/ 🚨 New TOXIC Fentalog quarterly report on multi-city toxicology testing shows fentanyl & other synthetic drugs dominate suspected overdose cases in US ERs. Findings offer a near real-time look at the street drug market. #medsky #PublicHealth 🧵
www.cfsre.org/nps-discover...
ToxIC Fentalog Study Group - Quarterly NPS Report: Q2 2025
www.cfsre.org
Reposted by Manini AF
Publication: Black patients less likely than white patients to receive outpatient treatment referrals after #opioid #overdose ED visits, per ToxIC Fentalog study. Findings underscore need to address disparities in post-overdose care. ➡️ bit.ly/4l1hFE2
@jamanetworkopen.com @maninialex.bsky.social
Reposted by Manini AF
🚨Publication Alert🚨 bit.ly/46U3nl6
#Xylazine found in 1 in 5 nonfatal #opioid #overdoses across 10 U.S. EDs, mostly alongside #fentanyl. Exposure highest in NE vs. rare in the West. Regional trends underscore need for targeted public health responses. #MedToxTuesday
@maninialex.bsky.social
Reposted by Manini AF
🚨Publication Alert🚨These findings focused on the presence of para-fluorofentanyl (PFF) point to important differences in OD response/treatment linked to fentanyl analogs w/ sex-specific effects that merit further investigation. 📖https://bit.ly/3Gv0gp3
@ziadkazzi.bsky.social @maninialex.bsky.social
Reposted by Manini AF
Among patients with opioid overdose in emergency departments, Black patients received outpatient referrals less frequently than White patients, with rates of 5.7% versus 9.6%. https://ja.ma/44kiKjO
July 1. Day One.
- You will feel overwhelmed (That’s normal)
- Courage isn't the absence of fear
- Ask for help early and often
- Nobody expects you to know everything
- Efficiency comes with time
- Trust the process
💙 Welcome. We’ve got your back. #InternYear #Medsky
Reposted by Manini AF
🚨HUGE SCIENCE WIN ALERT🚨

NIH Grants to be restored en masse!!! Thank you Judge Young for standing up for science!

#StandUpforScience
#SummerFightforScience
BREAKING: A federal judge in Massachusetts (the Reagan-appointed William Young) has declared the Trump administration's cuts to NIH grants — ostensibly over Trump's EOs on gender ideology and DEI — are "illegal" and "void." He's ordering many grants restored.
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Over the long term, proactive surveillance could shift care from reactive triage to prediction and prevention—offering a model for future responses to dynamic drug crises. #overdoseprevention
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Clinically, this research will explore whether current naloxone dosing suffices against these potent synthetics. ED docs may need new protocols if higher or novel reversal agents prove necessary. #EDpreparedness
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From a public health lens: amid >108,000 overdose deaths in 2023 and 70 % opioid-related, this study aims to integrate real-time data into the CDC Fentalog Nonfatal OD dashboard—enabling region‑specific alerts and proactive intervention. #publichealthalert
www.cdc.gov/overdose-pre...
The Fentalog Study: A Subset of Nonfatal Suspected Opioid-Involved Overdoses with Toxicology Testing
View substances detected in samples from patients experiencing a suspected opioid-involved overdose.
www.cdc.gov
1/
Exciting news: Our team has been awarded a NIDA R01 grant to fund "Fentalog II", a continuation of our groundbreaking collaboration to detect novel fentanyl analogue overdoses in EDs across ten major hospitals over five years. #syntheticopioids
#Medsky 🧵
www.mountsinai.org/about/newsro...
Mount Sinai Receives $3.8 Million Grant to Study New Synthetic Drugs and Opioid Overdoses in Emergency Departments to Prevent Deaths
www.mountsinai.org
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From a public health perspective, these findings underscore the hidden cardiovascular danger of common drugs like diphenhydramine, quetiapine, and loperamide in overdose. #poisonprevention #opioidepidemic
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QTc ≥500 ms alone isn’t the full picture. This paper gives clinicians a sharper triage lens: focus on the sickest patients, not just the longest intervals. #EDmedicine #riskstratification
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All three signs had strong associations with arrest, death, and ECMO need. Absence of all three? 98.2% NPV for dysrhythmia. #FOAMed #toxicology
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Only 3.8% of these patients developed ventricular dysrhythmias. But three simple ED findings—bradycardia, acidosis, and shock—were powerful red flags. #clinicaltox #ekgpearls