Lisa Situ
@lisasitu.bsky.social
330 followers
710 following
26 posts
Assistant Editor at Cancer Discovery, published by AACR.
BBS Harvard PhD '24 and proud UCLA Bruin.
Views are my own.
Link to sign up for Cancer Discovery News alerts: https://aacrjournals.org/pages/alerts
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Lisa Situ
@lisasitu.bsky.social
· Jun 12
Lisa Situ
@lisasitu.bsky.social
· Jun 12
Molecular Residual Disease Precedes Disease-Free Survival Events by Months
Major Finding: Molecular residual disease (MRD) preceded death or clinical recurrence in the ADAURA trial by nearly 5 months. Concept: Longitudinal MRD monitoring may stratify risk for patients with E...
aacrjournals.org
Lisa Situ
@lisasitu.bsky.social
· Jun 12
Lisa Situ
@lisasitu.bsky.social
· Jun 11
Ascites-derived Lipid Uptake Drives NK Cell Dysfunction in Ovarian Cancer
Major Finding: Lipids derived from ascites are taken up by NK cells and drive NK cell dysfunction in ovarian cancer.
Concept: Polar lipids such as phosphatidylcholine disrupt NK plasma membrane order ...
aacrjournals.org
Lisa Situ
@lisasitu.bsky.social
· Jun 11
SSRIs Elevate Intratumoral Serotonin and Enhance Antitumor Immunity
Major Finding: Serotonin transporter depletes intratumoral serotonin which dampens CD8+ T-cell antitumor immunity.Concept: Serotonin transporter inhibition with SSRIs drives T-cell antitumor immunity ...
aacrjournals.org
Lisa Situ
@lisasitu.bsky.social
· Jun 11
Cholesterol Metabolism Dictates Secondary Organ Colonization in Pancreatic Cancer
Major Finding: PCSK9 regulates cholesterol uptake and controls the trajectory of metastasis to secondary organs in pancreatic ductal adenocarcinoma (PDAC). Concept: Cholesterol uptake supports mTORC1-...
aacrjournals.org
Lisa Situ
@lisasitu.bsky.social
· Feb 13
Patient-Specific Hematologic Setpoints Inform Diagnosis and Prognosis
Main Findings: Complete blood count indices are patient-specific and stable over decades in healthy adults.Concept: These hematologic setpoints are deep physiological phenotypes associated with variat...
doi.org
Lisa Situ
@lisasitu.bsky.social
· Feb 13
Digoxin Reduces Circulating Tumor Cell Cluster Size in Breast Cancer
Major Finding: Digoxin treatment reduces circulating tumor cell cluster size in patients with metastatic breast cancer.Concept: Genes involved in cell–cell adhesion and cell cycle pathways are suppres...
doi.org
Lisa Situ
@lisasitu.bsky.social
· Feb 11
GDF-15 Blockade Overcomes Resistance to Immune Checkpoint Inhibition
Main Findings: Visugromab, a GDF-15 blocking antibody, is tolerable and elicits clinical responses in combination with nivolumab.Concept: GDF-15 may represent a mechanism of anti-PD-1 resistance that ...
doi.org
Lisa Situ
@lisasitu.bsky.social
· Feb 11
The Immune Evasin Nef Augments Allogeneic CAR T Function and Survival
Major Finding: HIV Nef expression reduces allorecognition and apoptotic cell death of CAR T cells.Concept: Controlled Nef expression reduces HLA-I levels and protects CAR T cells from CD8+ T cell– and...
doi.org
Lisa Situ
@lisasitu.bsky.social
· Feb 7
A Pediatric Pan-Cancer Cohort Enables the Study of Systemic Antitumor Immunity
Major Finding: An analysis of immune responses in children with cancer reveals the effects of age and tumor type. Concept: Pediatric tumors have varied mutational burden which correlates with immune c...
aacrjournals.org
Reposted by Lisa Situ
Nick Vitanza
@nickvitanza.bsky.social
· Jan 28
BrainChild-03 Trial Supports Safety of B7-H3 CAR T-cell Therapy for DIPG
Main Finding: A phase I trial supported the safety and feasibility of repeated intracranial infusions of B7-H3 CAR T cells for DIPG.Concept: B7-H3 is an immunoregulatory protein expressed on the surfa...
aacrjournals.org
Lisa Situ
@lisasitu.bsky.social
· Feb 7
Cancer Cells Induce T-Cell Dysfunction Through Mitochondrial Transfer
Major Finding: Cancer cells transfer mitophagy-resistant mitochondria to tumor-infiltrating lymphocytes (TIL) that impair antitumor activity. Concept: Deubiquitinase USP30 protects cancer cell-derived...
doi.org
Lisa Situ
@lisasitu.bsky.social
· Feb 6
Loss–Translocation–Amplification Chromothripsis Drives Osteosarcoma Evolution
Main Finding: High-grade osteosarcomas frequently exhibit a loss–translocation–amplification (LTA) pattern of chromothripsis that inactivates TP53 and amplifies oncogenes.Concept: Ongoing chromothrips...
doi.org
Lisa Situ
@lisasitu.bsky.social
· Feb 6
High-risk ER+ Breast Cancers Genomically Resemble HER2+ Tumors
Main Finding: HER2+ breast tumors and high-risk ER+ breast tumors share genomic features that reflect similar mechanisms of tumor evolution.Concept: The genomic architecture of breast cancer is constr...
doi.org
Lisa Situ
@lisasitu.bsky.social
· Jan 28
Nick Vitanza
@nickvitanza.bsky.social
· Jan 28
BrainChild-03 Trial Supports Safety of B7-H3 CAR T-cell Therapy for DIPG
Main Finding: A phase I trial supported the safety and feasibility of repeated intracranial infusions of B7-H3 CAR T cells for DIPG.Concept: B7-H3 is an immunoregulatory protein expressed on the surfa...
aacrjournals.org
Lisa Situ
@lisasitu.bsky.social
· Dec 6
Lisa Situ
@lisasitu.bsky.social
· Dec 5
Lisa Situ
@lisasitu.bsky.social
· Dec 5
The Liver X Receptor Axis Balances Intestinal Regeneration and Tumorigenesis
Major Finding: The liver X receptor (LXR) pathway drives intestinal regeneration and limits tumorigenesis.Concept: Transcriptomic and pharmacologic studies define a CYP27A1–LXR–TLS signaling axis in i...
aacrjournals.org
Lisa Situ
@lisasitu.bsky.social
· Dec 5
Lisa Situ
@lisasitu.bsky.social
· Dec 4
Oncolytic Virotherapy Plus Nivolumab Is Safe in Muscle-Invasive Bladder Cancer
Major Finding: A phase 1b trial demonstrated the safety of cretostimogene grenadenorepvec plus nivolumab in muscle-invasive bladder cancer (MIBC).Concept: Boosting immune checkpoint inhibition with on...
aacrjournals.org
Lisa Situ
@lisasitu.bsky.social
· Dec 2
Lisa Situ
@lisasitu.bsky.social
· Dec 2
GD2-CAR T-cell Therapy is Safe in H3K27M+ Diffuse Midline Glioma
Main Finding: A phase I clinical trial demonstrates the safety of GD2-targeted CAR T-cell therapy in H3K27M+ diffuse midline glioma.Concept: H3K27M+ diffuse midline gliomas express high levels of GD2,...
doi.org
Lisa Situ
@lisasitu.bsky.social
· Nov 27
APOBEC3-Mediated Mutations Promote CCND1 ecDNA Biogenesis in Bladder Cancer
Major Finding: APOBEC3-associated mutagenesis and ecDNA formation coordinately drive urothelial cancer evolution.Concept: ecDNA events enable adaptive resistance to chemotherapy.Impact: This study del...
doi.org