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Lifespan News

Lifespan News

@lifespannews.bsky.social

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The latest longevity and rejuvenation biotechnology news.

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Lifespan News @lifespannews.bsky.social · 14h

A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin.
Boosting their function with a growth factor offers a possible avenue for anti-aging interventions.
www.lifespan.io/news/skin-ag...
By: @arkadimazin.bsky.social

Skin Aging Underlined by Loss of Capillary Macrophages

A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 1d

The October Rejuvenation Roundup is here!

Catch up on news about our campaign for public longevity, new organization: Alliance for Longevity Science, Arts & Entertainment (ALSAE), interviews with leaders in the longevity field & more!

Learn more:
www.lifespan.io/news/rejuven...

Rejuvenation Roundup October 2025

The trick-or-treaters have all gone home as the leaves have fallen to the ground, but rejuvenation biotech attempts to prevent human beings from fading […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 4d

How much exercise🏃do you need to reduce cardiovascular heart disease risk?

If you are a male♂️, you need to work twice as hard as a female♀️to achieve the same benefits, a new study suggests.

www.lifespan.io/news/men-mig...
By: @arkadimazin.bsky.social

Men Might Need More Exercise to Lower Cardiovascular Risks

A new observational study suggests that men need more than twice as much exercise as women do to achieve the same level of reduction in […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 5d

Researchers have found that the efficiency of autophagy, a cellular maintenance process, doesn't decline in every aging cell.
In some T cells derived from healthy older people, autophagy increases rather than decreases.

www.lifespan.io/news/mainten...
By: Josh Conway

Maintenance Stays Efficient in Healthy Older People’s Cells

Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. […]

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Lifespan News @lifespannews.bsky.social · 6d

A recent study discovered an association between visceral and hepatic fat with cardiovascular risk factors and carotid atherosclerosis.

www.lifespan.io/news/organ-f...
By: @drangowskaway.bsky.social

Organ Fat Is Associated With Carotid Atherosclerosis

A recent study discovered an association between visceral and, to a lesser extent, hepatic fat with cardiovascular risk factors and carotid atherosclerosis. This association persists even after adjust...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 7d

Some chronic infections, which linger in the body and are not cleared out by the immune system, can drive cellular senescence and aging.

A recent review discusses various mechanisms behind this connection.

www.lifespan.io/news/review-...
By: @arkadimazin.bsky.social

Review Links Lingering Infections to Senescence

In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging [1]. Lurking in the body People are mostly aware of acute infection...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 8d

A study investigated the impact of mechanical forces on cellular biology.
The researcher found that the extracellular matrix (ECM) stiffness encourages cells to undergo senescence.

www.lifespan.io/news/stiff-c...
By: Josh Conway

Stiff Collagen May Lead to Senescent Cells

A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence. An unexplored relationship ECM stiffness and cellular […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 11d

🧠A study suggests that an unholy duo of two proteins, amyloid and fibrinogen, causes harm in much lower concentrations than either of them alone.

This observation can offer new directions for the study of Alzheimer’s.

www.lifespan.io/news/amyloid...
By: @arkadimazin.bsky.social

Amyloid-Fibrinogen Complexes Exacerbate Alzheimer’s in Mice

A study from Rockefeller University suggests that an unholy duo of two proteins causes harm in much lower concentrations than either of them alone. This points to a […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 12d

What’s the biological age of your dog? 🐕

Researchers working with data from the Dog Aging Project found that some amino acids generated from protein metabolism are more common in older dogs and can help determine the biological ages of dogs.

www.lifespan.io/news/measuri...
By: Josh Conway

Measuring Dog Aging With Protein Metabolism

Researchers working with data from the Dog Aging Project have found that post-translationally modified amino acids (ptmAAs), which are generated from protein metabolism, […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 12d

In our recent interview, Lifespan News talked with Dr. Andrea Maier, who has been working on bringing longevity medicine to the masses.

We have discussed Andreas's work and the importance of training physicians in longevity medicine.

www.lifespan.io/news/andrea-...
By: @arkadimazin.bsky.social

Andrea Maier on Longevity Medicine for All

Dr. Andrea Maier, Oon Chiew Seng Professor in Medicine at the National University of Singapore, is a veteran geroscientist and one of […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 13d

Researchers demonstrated a proof-of-concept for turning lipid injection, directly into the retina, into a possible therapy for age-related vision decline.👀
In a new study such treatment partially reversed vision decline in mice.
www.lifespan.io/news/address...
By: @drangowskaway.bsky.social

Addressing Age-Related Vision Decline With Lipid Supplements

Researchers have partially reversed age-related vision decline in mice by injecting lipids directly into the retina [1]. The lipids in the […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 14d

🧠Scientists have developed a novel multicellular integrated brain model to study neurological diseases, incorporating all six major brain cell types derived from patient-specific induced pluripotent stem cells.
www.lifespan.io/news/tiny-br... @alicestanton.bsky.social
By: @arkadimazin.bsky.social

Tiny Brain Organoids Show Promise in Alzheimer’s Research

Scientists have developed a novel multicellular integrated brain model to study neurological diseases, incorporating all six major brain cell types derived from patient-specific induced pluripotent st...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 15d

What experiments conducted in space🛰️tell us about stem cells?
Researchers report positive results, e.g., some organoids grow much faster under microgravity conditions than on Earth, but there are also some negative effects.
You can learn more from our recent piece👇
www.lifespan.io/news/how-bei...

How Being in Orbit Affects Stem Cells

In Cell Stem Cell, researchers from the Cedars-Sinai Medical Center have published a review discussing what experiments conducted in space can do for stem cell research and medical research as […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 18d

Scientists have found that a gene on the X chromosome, 🧬which escapes silencing, promotes inflammation 🔥 and neurodegeneration 🧠in a mouse model of multiple sclerosis, but the effects can be reversed with metformin. 💊

www.lifespan.io/news/female-...
By: @arkadimazin.bsky.social

Female-Specific Mechanism of Neurodegeneration Discovered

Scientists have found that a gene on the X chromosome, which escapes silencing, promotes inflammation and neurodegeneration in a mouse […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 19d

Researchers have discovered that infrared lasers promote the clearance of toxic metabolites from the aged mice's brains, improving cognition. 🧠
Similar approaches have been previously used in humans with brain damage and have had positive results.
www.lifespan.io/news/infrare...
By: Josh Conway

Infrared Lasers Clear Harmful Compounds in Mouse Brains

Researchers have discovered that infrared lasers promote the clearance of toxic metabolites from the brains of age-accelerated mice by improving lymphatic drainage. Gunking up the works Advanced glyca...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 20d

A new report from the Interventions Testing Program adds three new compounds to the list of lifespan-extending compounds confirmed during their experiments.
However, these compounds extend lifespan only in male ♂️ mice.🐁
www.lifespan.io/news/interve...
By: @drangowskaway.bsky.social

Interventions Testing Program Finds Three New Compounds

A new report from the Interventions Testing Program adds three new compounds to the list of lifespan-extending compounds confirmed during their experiments: epicatechin, halofuginone, and mitoglitazon...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 21d

Scientists have found that naked mole rats, a famously long-lived species, produce a unique (and apparently improved) version of a DNA 🧬 repair protein, which is boosting their DNA repair process.

www.lifespan.io/news/why-nak...
By: @arkadimazin.bsky.social

Why Naked Mole Rats Have Better DNA Repair

Scientists have found that the cGAS protein in naked mole rats, a famously long-lived species, boosts DNA repair, while the human version tends to […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 22d

A new study described core genes🧬 that appear to be causal drivers of aging, providing a list of key targets for further studies.
Those genes are consistently changed over various tissues and species, and inactivating them in adulthood extends lifespan in worms.

www.lifespan.io/news/researc...

Researchers Identify Key Age-Related Genes

In Aging Cell, researchers have described core genes that apply to a wide variety of species and appear to be causal drivers of aging. Looking for signals in the noise Introducing their study, the res...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 25d

Scientists have created nanoparticles that latch onto a master regulator of amyloid-beta clearance, diverting it towards a more efficient route.
The treatment:
🧠drained Aβ from mouse brains and
🧠restored cognition to near wild-type levels.
www.lifespan.io/news/nanopar...
By: @arkadimazin.bsky.social

Nanoparticles Potently Reverse Alzheimer’s in Mice

Scientists have created polymersomes, a type of nanoparticle, that latch onto a master regulator of amyloid-beta clearance, diverting it towards a more efficient route. […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 26d

A group of researchers recently showcased their creation of PASS GERO, a public-facing, free application that allows researchers to evaluate potential anti-aging compounds.

www.lifespan.io/news/a-publi...
By: Josh Conway

A Public Website for Evaluating Potential Anti-Aging Drugs

Researchers publishing in the International Journal of Molecular Sciences have showcased their creation of PASS GERO, a public-facing application that allows researchers to evaluate potential anti-agi...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 27d

Plenty of preclinical studies investigated rapamycin and showed its benefits in model organisms. However, can rapamycin extend healthspan and lifespan in healthy humans?
A review of clinical studies sheds light on that question.
www.lifespan.io/news/impact-...
By: @drangowskaway.bsky.social

Impact of Off-Label Low-Dose Rapamycin on Healthy Adults

A team of scientists has reviewed the clinical data regarding low-dose rapamycin therapy in healthy adults. They concluded that, while there is plenty of preclinical data regarding the impact of rapam...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · 29d

A recent study explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability in older animals.

www.lifespan.io/news/partial...
By: Josh Conway

Partial Reprogramming Enhances Nerve Repair in Rats

In Advanced Science, a team of researchers has explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability to older animals. Stress as a signal This paper focus...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · Oct 3

Matter Bioworks has a bold vision of tackling one of the hallmarks of aging -DNA damage.
Lifespan News talked to Sam Sharifi, Matter Bio’s Chief Scientific Officer, about the company’s philosophy, technology, research programs, and future.
www.lifespan.io/news/sam-sha...
By: @arkadimazin.bsky.social

Sam Sharifi on Fixing Our DNA | Lifespan Research Institute

Among the hallmarks of aging, DNA damage is both one of the most important and one of the hardest to crack. A […]

www.lifespan.io

Lifespan News @lifespannews.bsky.social · Oct 2

Using an AI model, Retro Biosciences was able to tweak some of the existing reprogramming factors, greatly improving reprogramming efficiency.
We talked to Joe Betts-Lacroix about this announcement and other exciting Retro-related topics.
www.lifespan.io/news/joe-bet...
By: @arkadimazin.bsky.social

Joe Betts-Lacroix on Retro Bio and Its Recent AI Advancement

Retro Biosciences, one of the hottest startups in the longevity field, was founded about five years ago by the tech entrepreneur Joe Betts-Lacroix with a $180 million investment from his friend Sam Al...

www.lifespan.io

Lifespan News @lifespannews.bsky.social · Oct 2

A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 💊 depends on the cellular division stage at which the cell became senescent.

www.lifespan.io/news/cell-cy...
By: @drangowskaway.bsky.social

Cell Cycle Stage Impacts the Efficacy of Senotherapeutics

A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based […]

www.lifespan.io