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Reposted by Katharina Geißler

Jan Philipp Kreysing @jpkreysing.bsky.social · 6d

❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...

cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography - Communications Biology

Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.

www.nature.com

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Katharina Geißler @kgeissler.bsky.social · Aug 21

great lipid probes promising exciting studies for (membrane) cell bio, such fascinating work!

Nature @nature.com · Aug 21

Nature research paper: Quantitative imaging of lipid transport in mammalian cells

go.nature.com/4mmSygd

Quantitative imaging of lipid transport in mammalian cells - Nature

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

go.nature.com

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Reposted by Katharina Geißler

Nikolai Slavov @slavov-n.bsky.social · Jul 3

The 3-decade-old competition that enabled the emergence and evaluate of AlphaFold has run out of NIH funding.

The program will be terminated in weeks.

This is terminating success.

www.science.org/content/arti...

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Reposted by Katharina Geißler

SCALE - SubCellular Architecture of LifE @scale-cluster-ffm.bsky.social · May 23

🎉 We’re absolutely thrilled: SCALE has been selected as a DFG Excellence Cluster!
A huge thank you to our incredible team—this would not have been possible without your dedication and talent. 🙌 @dfg.de
#ClustersOfExcellence #SCALEcluster 🧵

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Katharina Geißler @kgeissler.bsky.social · Apr 12

Beautiful work by JP, Sergio, Johannes and colleagues!

Jan Philipp Kreysing @jpkreysing.bsky.social · Apr 11

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

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Reposted by Katharina Geißler

Jan Philipp Kreysing @jpkreysing.bsky.social · Apr 9

Excited to share our latest work on nuclear pore complex scaffold integrity and its perturbation. Now out in Nature Cell Biology: rdcu.be/eg4i9
Great work by Reiya Taniguchi who just opened his own research group back in Japan! 🥳

Nuclear pores safeguard the integrity of the nuclear envelope

Nature Cell Biology - Taniguchi et al. structurally analyse nuclear pore complex architecture in situ during differentiation, which is associated with mechanical constraints on the nuclear...

rdcu.be

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Katharina Geißler @kgeissler.bsky.social · Mar 15

Another method from our lab on biorxiv! Automated classification and removal of flawed tilts in cryo ET data

bioRxivpreprint @biorxivpreprint.bsky.social · Mar 15

Automated Removal of Corrupted Tilts in Cryo-Electron Tomography https://www.biorxiv.org/content/10.1101/2025.03.13.642992v1

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Katharina Geißler @kgeissler.bsky.social · Mar 15

Check out @deglushk.bsky.social 's method to measure membrane thickness in cryo electron tomograms!

bioRxivpreprint @biorxivpreprint.bsky.social · Mar 14

In situ evidence for systematic membrane thickness variation across cellular organelles https://www.biorxiv.org/content/10.1101/2025.03.13.642912v1

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