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Joshua Fein

@joshuafein.bsky.social

490 followers 760 following 83 posts

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Joshua Fein @joshuafein.bsky.social · Dec 13

It’s been 13 years since I started down the road to a medical career and left music behind… but I’m delighted to say that last night I had my got to sing on a stage again for the first time in about a decade! Hoping to make time for voice lessons and occasional performing as an attending

Impossible Dream

This is "Impossible Dream" by Joshua Fein on Vimeo, the home for high quality videos and the people who love them.

vimeo.com

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Joshua Fein @joshuafein.bsky.social · 5d

Still can’t believe this isn’t the world’s most elaborate April fools joke… in October. Can’t wait to try it, and put in an order for a tshirt 🙃 thanks for all you do for the community to keep us sane: both the memes and the tools/wisdom!

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Joshua Fein @joshuafein.bsky.social · 5d

Congrats to the authors on this huge accomplishment. Fascinating and so much to build on here.

Jeremy Barr @jeremyjbarr.bsky.social · 5d

Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...

PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.

Isolation, engineering and ecology of temperate phages from the human gut - Nature

Human host-associated cellular products may act as induction agents for bacteriophages.

nature.com

Joshua Fein @joshuafein.bsky.social · Aug 13

Has anyone had success 3D printing storage boxes for -80s? What fiber have you used? any special settings to reinforce?
I'm thinking of making either custom inserts or entire boxes to better keep track of which sample goes where...

Reposted by Joshua Fein

Ben Langmead @benlangmead.bsky.social · May 29

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

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Joshua Fein @joshuafein.bsky.social · Apr 27

Reminds me of Oliver Sacks’ musings on seeing azure.
This will surely be commercialised and available as an “experience” (hopefully safely) around the world soon, but absolutely sign me up.

The ‘Profound’ Experience of Seeing a New Color

The ecstasy of “olo”

www.theatlantic.com

Joshua Fein @joshuafein.bsky.social · Apr 23

I think the reason I like #systemsimmunology #cshlsysimm is because network diagrams are so pretty.

Joshua Fein @joshuafein.bsky.social · Apr 23

This is simply insanity.

STAT @statnews.com · Apr 22

Federal funding for the Women’s Health Initiative, which as one of the largest research projects in women’s health has shaped treatment of menopause, osteoporosis, and nutrition, will stop in September.

Women’s Health Initiative, known for hormone therapy trials, to lose federal funding

The Women's Health Initiative, the enormous study that shaped treatment of menopause and other conditions, is on the verge of shutting down.

buff.ly

Joshua Fein @joshuafein.bsky.social · Apr 19

Congrats!

Joshua Fein @joshuafein.bsky.social · Apr 19

This disc is a revelation.
I thought I knew these pieces-the D minor concerto was one of the first pieces I fell in love with as a kid.
Beatrice Rana’s playing is simply enchanting.

Bach: Keyboard Concertos, BWV 1052, 1053, 1054 & 1056 by Beatrice Rana - Apple Music Classical

Listen to Bach: Keyboard Concertos, BWV 1052, 1053, 1054 & 1056 by Beatrice Rana. 2025. 12 tracks. 1 hour, 2 minutes.

classical.music.apple.com

Joshua Fein @joshuafein.bsky.social · Apr 18

Does anyone have experience with momelotinib for AGvHD in MF patients?

Reposted by Joshua Fein

Simone Minnie @simone-minnie.bsky.social · Apr 17

I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested!

aprecruit.ucsf.edu/JPF05438

Minnie Lab - Junior, Assistant, or Associate Specialist

University of California, San Francisco is hiring. Apply now!

aprecruit.ucsf.edu

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Joshua Fein @joshuafein.bsky.social · Apr 16

Excited to attend #cshlsysimm next week. I am just starting to find my way in this fascinating field and look forward to learning from the extraordinary lineup of speakers! Please reach out if you’ll be there—looking forward to connecting. @cshlnews.bsky.social

Joshua Fein @joshuafein.bsky.social · Apr 11

I remain strongly in favor of fishing expeditions.

mad scientist wearing a bowtie fishing and catches a beaker of orange bubbling liquid

Joshua Fein @joshuafein.bsky.social · Apr 11

Oof. So much for my theory that the more you can identify a cartoon character in your UMAP the better your results.
If there is a publicly shared video of the talk please post the link!

Joshua Fein @joshuafein.bsky.social · Apr 9

In light of recent news regarding funding, I have asked ChatGPT to help figure out how to do ATAC-Seq with only an abacus and stone tools.

Neolithic people working with mortar and pestle on an ATAC-seq analysis. An older man holds a bottle labeled Tn5 Transposase

Reposted by Joshua Fein

Asma Farhat @asmafarhat.bsky.social · Mar 28

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis.
🔗 www.science.org/doi/10.1126/...

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence

Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

www.science.org

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Joshua Fein @joshuafein.bsky.social · Mar 20

It dawned on me today that I really should’ve named one of my kids Luke, so that I could legitimately say “Luke, I am your father.”

Oh well.

Joshua Fein @joshuafein.bsky.social · Mar 18

Shame on me for living in the US Northeast and only visiting our neighbors twice in my life (and not in the last 20 years!) Québec City looks like a stunning place to live, though it'll take me some time to acclimate to the arctic.

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Joshua Fein @joshuafein.bsky.social · Mar 18

Today is another Chopin day.
Thank you, Maurizio Pollini.
music.apple.com/us/album/pia...

Piano Sonata No. 3 in B Minor, Op. 58: II. Scherzo (Molto vivace) by Maurizio Pollini on Apple Music

Song · 2019 · Duration 2:31

music.apple.com

Joshua Fein @joshuafein.bsky.social · Mar 18

...O Canada, my future home and to-be-native land?

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Joshua Fein @joshuafein.bsky.social · Mar 17

Highly recommended escape from these dark times.

The Road to 1066: Anglo-Saxon Apocalypse (Part 1)

Podcast Episode · The Rest Is History · 03/17/2025 · 55m

podcasts.apple.com

Reposted by Joshua Fein

danapeer.bsky.social @danapeer.bsky.social · Mar 7

1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer

Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic ...

www.biorxiv.org

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Joshua Fein @joshuafein.bsky.social · Mar 6

Having determined that the transplant immunology community is shamefully lacking for pompously named journals, I propose the establishment of Acta Transplantiana A (solid organs) and B (haematopoietic tissues).
Paper distribution only, on heavy cream-coloured paper stock. Figures hand-drawn.

Joshua Fein @joshuafein.bsky.social · Mar 2

This looks fantastic. Have the perfect dataset to test it in, too.