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Joris Deelen @jorisdeelen.bsky.social · 17d

And that was the end of part 2, an inspiring G-JAM conference in Jena with many exciting talks! Next up the TWIN4EarLiStAge HorizonEU Twinning Project Training Course in the Biology of Aging in Crete and the Biomarkers of Aging Consortium meeting in Boston!

Joris Deelen @jorisdeelen.bsky.social · Sep 8

Conference season has officially started! I had a great time in Berlin last week @ComLab10 organised by the Alexander von Humboldt Foundation where I talked about our work on the genetics of human longevity. It was an inspiring meeting and I was really impressed by the pitches from the participants!

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Adam Rutherford @adamrutherford.bsky.social · 21d

Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.

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delladavid-lab.bsky.social @delladavid-lab.bsky.social · 26d

🔬We have a fully funded Cambridge Biosciences DTP PhD postion to study #Proteostasis and #Aging in colloboration with @jrkumita.bsky.social @Pharmacology. Details on the project ▶️https://tinyurl.com/2zhkjjhs + bbsrcdtp.lifesci.cam.ac.uk/how-apply . Please RT.

tinyurl.com

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Joris Deelen @jorisdeelen.bsky.social · Sep 13

This study helps to shed some light on the biological mechanisms underlying the association of MetaboHealth with ageing-related outcomes paving the way for targeted lifestyle interventions in at risk individuals.

More on this to follow soon!

@molepi.bsky.social
@bds-lumc.bsky.social

Joris Deelen @jorisdeelen.bsky.social · Sep 13

Great to see this paper by Daniele Bizzarri now published in Immunity & Ageing! Here we show that a higher MetaboHealth score is associated with increased inflammatory/immune related proteins and decreased cholesterol transport related proteins.

🧪

immunityageing.biomedcentral.com/articles/10....

Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport - Immunity & Ageing

The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth...

immunityageing.biomedcentral.com

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Stephanie A. Fernandes @stephalcantara.bsky.social · Sep 11

My new lab at the MPI Age is looking for a postdoc in skeletal muscle cell and molecular biology! If you’re a curious and motivated scientist and would like to apply, check the details below:

MPI for Biology of Ageing @mpiage.bsky.social · Sep 11

🚨 Job alert! The Fernandes Lab is looking for a postdoc (m/f/d)! Apply now!

mpi-age.de.umantis.com/Vacancies/49...

@stephalcantara.bsky.social @cecad.bsky.social

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Joris Deelen @jorisdeelen.bsky.social · Sep 8

@molepi.bsky.social @bds-lumc.bsky.social @mpiage.bsky.social

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Joris Deelen @jorisdeelen.bsky.social · Sep 8

Now traveling to Tartu for the 24th Gene Forum organised by the Institute of Genomics where I will present our work on metabolomics-based biomarkers of ageing. It will be my first genomics conference in years, so I look forward to hear about the latest breakthroughs in the field!

geneforum.ee

Gene Forum 2025 – International Gene Conference

geneforum.ee

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Joris Deelen @jorisdeelen.bsky.social · Sep 8

Conference season has officially started! I had a great time in Berlin last week @ComLab10 organised by the Alexander von Humboldt Foundation where I talked about our work on the genetics of human longevity. It was an inspiring meeting and I was really impressed by the pitches from the participants!

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Reposted by Joris Deelen

Ina Huppertz @inahuppertz.bsky.social · Aug 24

🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...

#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells

Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...

doi.org

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Arwen Gao @arwengao.bsky.social · Aug 19

Registration is now open! As one of the organizers, I am looking forward to meeting all the aging researchers in the Netherlands at our annual meeting!
dusra.nl/annual-meeti...
#DuSRA #AmsterdamUMC #Agingresearch #Netherlands

Annual meeting 2025

Welcome message from the organizing committee In 2025, the Dutch Society for Aging Research (DuSRA) is proud to host its Annual Scientific Meeting on 10–11 November 2025 in Amsterdam. Over two days, ...

dusra.nl

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Trentini Lab @trentini-lab.bsky.social · Aug 1

🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...

Principles of ribosome-associated protein quality control during the synthesis of CFTR

Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...

www.biorxiv.org

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Sophie Steculorum @sophiesteculorum.bsky.social · Jul 29

Grateful to @maxplanck.de ‬for featuring our recent paper in their amazing new video! 🎥🌟 Thank you for the wonderful spotlight on our work! 🙌😄

Max-Planck-Gesellschaft @maxplanck.de · Jul 29

Yummy, das riecht gut! 🥘 Essensduft aktiviert bestimmte Nervenzellen in #Gehirn, die das Hungergefühl verringern. Deshalb haben wir nach dem Kochen, oft keinen #Appetit mehr. Der erste #Heißhunger ist verflogen: youtu.be/HTPll7fLl3c #Ernährung

Sättigungsgefühl durch Gerüche: Kann man sich satt riechen und Heißhunger einfach wegriechen?

YouTube video by MaxPlanckSociety

youtu.be

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Joao Pedro Magalhaes @jpsenescence.bsky.social · Jul 28

New preprint with our list of 100 open problems in ageing science.

Our curated list captures both long-standing fundamental questions and emerging research frontiers.

A massive team effort by >30 researchers from many disciplines in biogerontology.

arxiv.org/abs/2507.18602

Open problems in ageing science: A roadmap for biogerontology

The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...

arxiv.org

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Joris Deelen @jorisdeelen.bsky.social · Jul 17

Very proud of Niels van den Berg who managed to secure a prestigious Veni grant from NWO! It is really great that he can now expand his research line on socioeconomic factors influencing health within families as part of our Ageing group within @molepi.bsky.social @bds-lumc.bsky.social!

Biomedical Data Sciences at LUMC @bds-lumc.bsky.social · Jul 17

📢 Niels van den Berg has been awarded a €320,000 Veni grant from NWO for his research on how socioeconomic resources, behaviour, and genes affect health within families. Proud of Niels! 👏🥂
More info👇

www.nwo.nl/en/news/200-...

#NWO #veni #Causality #BDS-MOLEPI #LUMC #HealthCampustheHague

200 onderzoekers ontvangen Veni-beurs | NWO

Binnen jeugdbeschermingstrajecten identificeren wanneer de kans op uithuisplaatsingen van kinderen het grootst is. De kwaliteit van operaties verbeteren met videoanalyse. De wisselwerking tussen wind en vegetatie voor het optimaliseren van de weerbaarheid van kustduinen. Betrouwbare algoritmes ontwikkelen voor statistisch leren met interactieve besliskunde. Dit zijn vier van de tweehonderd onderzoeksprojecten van wetenschappers die een Veni-beurs hebben gekregen. Elke onderzoeker krijgt maximaal 320.000 euro toegewezen. De beurs is een stimulans voor avontuurlijke, talentvolle en baanbrekende onderzoekers om de komende drie jaar hun eigen onderzoeksideeën verder te ontwikkelen.

www.nwo.nl

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Molecular Epidemiology at LUMC @molepi.bsky.social · Jul 17

The MolEpi group congratulates Niels van den Berg with his Veni grant! 👏🥂

📝 Title of the project: Spousal survival Advantage by Marrying into longevity Enriched families (SAME)

👉 www.nwo.nl/en/news/200-...

#NWO #veni #grant #Causality #BDS-MOLEPI #LUMC #ODDISEI #DataScience #HealthCampustheHague

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delladavid-lab.bsky.social @delladavid-lab.bsky.social · Jul 4

We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social

hireful.

tinyurl.com

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Joris Deelen @jorisdeelen.bsky.social · Jun 27

Congratulations @cochemelab.bsky.social!

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Maria Ermolaeva @mariaermolaeva.bsky.social · Jun 22

One week left until the abstract submission deadline. Excellent line-up of speakers discussing diverse topics on aging and longevity and 20+ slots for short talks selected from the abstracts. Don't miss your chance to join us in Jena in September!

Maria Ermolaeva @mariaermolaeva.bsky.social · May 22

Interested in healthy aging - from fundamental mechanisms to advanced interventions? Join us September 24-26 for the Groningen-Jena Aging Meeting, featuring talks by leading experts and 20+ short talk slots selected from abstracts. Early bird registration ends on 30.06.25

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Joris Deelen @jorisdeelen.bsky.social · Jun 11

Congratulations Sophie!

Joris Deelen @jorisdeelen.bsky.social · Jun 11

liveforever.club/article/rare...

Rare gene mutations may explain why some people live much longer

These changes may help people stay healthy as they grow older

liveforever.club

Joris Deelen @jorisdeelen.bsky.social · Jun 3

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Reposted by Joris Deelen

Nature Aging @nataging.nature.com · Jun 2

Online now!✨RESEARCH: Gkioni et al @mpiage.bsky.social show that trametinib and rapamycin treatment combine additively to extend lifespan and healthspan in female and male mice, reducing tumor growth and inflammation www.nature.com/articles/s43... rdcu.be/eo3gS

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan - Nature Aging

Gkioni et al. show that trametinib, which targets the Ras–Mek–Erk pathway, extends lifespan in male and female mice and that co-treatment with the known geroprotector rapamycin additively extends life...

www.nature.com

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Nathan Woodling @nathanwoodling.bsky.social · Jun 1

We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).

Header with images of cultured cells and a Drosophila brain. Text below reads:

We are excited to be recruiting our team of 3 post-doctoral research fellows to study the mechanisms underlying ageing-dependent glial cell dysfunction and its effects on neurodegeneration! This is a three-year Medical Research Council-funded cross-disciplinary, multi-partner project with one post-doctoral fellow at each site: Edinburgh Napier, University of Glasgow, and UCL. If you are interested in glial cell biology/neurodegeneration, functional genomics and bioinformatics please get in touch or apply below: Astrocyte ageing & Bioinformatics: Fiona Kerr, ENU (f.kerr@napier.ac.uk): Apply here: Closing Date: https://jobs.napier.ac.uk/mthrprod_webrecruitment/wrd/run/etrec179gf.open?WVID=150547JMmr&LANG=USA Tuesday 24th June 2025 Microglial Ageing & Bioinformatics: Dervis Salih, UCL (dervis.salih@ucl.ac.uk): Apply here: https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?jobId=35013&jobTitle=Research+Fellow Closing Date: Thursday 26th June 2025
Drosophila models of neurodegeneration: Nathan Woodling, University of Glasgow (nathan.woodling@glasgow.ac.uk): Apply here: https://www.jobs.gla.ac.uk/job/research-associate-49?source=gla.ac.uk Closing Date: Wednesday 25th June 2025

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Lamming Lab @lamminglab.bsky.social · May 30

Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.
www.legacy.com/us/obituarie...

THOMAS BLACKWELL Obituary (1957 - 2025-05-09) - Boston, MA - Boston Globe

View THOMAS KEITH BLACKWELL's obituary, send flowers and sign the guestbook.

www.legacy.com

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