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Irina Bezsonova @irinabezsonova.bsky.social · 1d

Our new paper is finally out today. An exciting collaboration with the Buhrlage lab. We report an allosteric activator of USP7.
www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Irina Bezsonova @irinabezsonova.bsky.social · 1d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 13
Prompt DRINK
Pdb: 7BTW

A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer.
Cheers!

Next: TRUNK
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 2d

Yes, but… I drew alcohol dehydrogenase before.

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Irina Bezsonova @irinabezsonova.bsky.social · 2d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 12
Prompt SHREDDED
Pdb: 6TUB

β-Endorphin.
The protein precursor POMC is shredded by proteases into multiple peptide hormones, including β-endorphin.

Next: DRINK
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 2d

Thank you

Irina Bezsonova @irinabezsonova.bsky.social · 3d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 11
Prompt STING
Pdb: 6MZT

Scorpion venom protein Urotoxin.

Next:SHREDDED
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 3d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 10
Prompt SWEEP
Pdb: 7NAP

Proteasome: the cleanup machine. It breaks down damaged or unneeded proteins, keeping the cell neat and efficient.

Next: STiNG
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 3d

A fantastic place to work and live!

Daniel Durocher @durocher1.bsky.social · 4d

9 days to go:
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!

Daniel Durocher @durocher1.bsky.social · Aug 28

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

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Irina Bezsonova @irinabezsonova.bsky.social · 4d

Love this idea! Thanks.

Irina Bezsonova @irinabezsonova.bsky.social · 5d

🤔

Irina Bezsonova @irinabezsonova.bsky.social · 5d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 9
Prompt HEAVY
Pdb: 4DL6

Heavy metal therapy. Platinum-based cancer drug cisplatin damages DNA but DNA polymerase eta manages to copy it past the lesion.

Next: SWEEP
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 6d

Thank you

Irina Bezsonova @irinabezsonova.bsky.social · 6d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 8
Prompt RECKLESS
Pdb: 5TZO

A reckless surge. Two molecules of fentanyl engulfed by its computationally designed binder Fen49*

Next: HEAVY
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 6d

Week 1 of first drafts :)

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Irina Bezsonova @irinabezsonova.bsky.social · 7d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 7
Prompt STARFISH
Pdb: 6KG7

Starfish relies on sensory information.
This is Piezo 2 - mechanically activated ion channel responsible for the sense of touch.

Next: RECKLESS
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 8d

Thanks!

Irina Bezsonova @irinabezsonova.bsky.social · 8d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 6
Prompt PIERCE
Pdb: 8HO3 8HQO 8HQZ 8HRE 8HRG

Structure of a bacteriophage DT57C that carries a special piercing tip to attack bacteria.

Next: STARFISH
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 9d

You know, I agree. How about in 2027 we feature ubiquitin in all prompts? Maybe an occasional E3 or a DUB :)

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Irina Bezsonova @irinabezsonova.bsky.social · 9d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 5
Prompt DEER
Pdb 4YXH

Two molecules of a deer prion protein decorate its head. Misfolded prions can make other prions to misfold causing neurodegenerative diseases in mammals.

Next: PIERCE
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 9d

I’m glad you approve! Any ideas for deer?

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Irina Bezsonova @irinabezsonova.bsky.social · 10d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 4
Prompt MURKY
Pdb 8T1M

Domain with unidentified function 1842 from pathogenic bacteria (thanks Leah)

There are many proteins with known structures but their function remains murky.

Next DEER

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Irina Bezsonova @irinabezsonova.bsky.social · 11d

Love this!

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Irina Bezsonova @irinabezsonova.bsky.social · 11d

This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 3/31
Prompt CROWN

Coronavirus spike protein. The crown sits on one of its three receptor-binding domains - a key element for successful infection.

Pdb: 6ZWV

Next prompt is MURKY and I’m at loss

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Irina Bezsonova @irinabezsonova.bsky.social · 12d

This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 2/31
Prompt WEAVE

N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms.

Pdb: 3UA0

Next prompt is CROWN and I would love your suggestions!

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Irina Bezsonova @irinabezsonova.bsky.social · 13d

What a great suggestion!