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Reposted by JCI insight

The American Society for Clinical Investigation @the-asci.org · 19h

Autosomal-dominant polycystic kidney disease is caused by PC1/PC2 mutations, but how the WT proteins prevent cysts was unclear

ASCI member Chou-Long Huang & team reveal they form receptor-channel complexes activated by external ligands that regulate Ca2+ signaling: insight.jci.org/articles/vie...

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JCI insight @insight.jci.org · 23h

Epigenetic scarring after chronic infection or cancer can lock immune cells into a dysfunctional state.

Here, Hazem E. Ghoneim @hazemghoneim.bsky.social & team develop an in vitro model of terminal CD8+ T cell dysfunction that better mimics in vivo exhaustion.

insight.jci.org/articles/vie...

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The American Society for Clinical Investigation @the-asci.org · 1d

Pseudohypoparathyroidism type 1B is linked to the GNAS locus, but identifying the molecular underpinnings in “sporadic” cases has been a challenge.

Here, ASCI member Harald Jüppner & team connect SNVs with imprinting defects, clarifying “sporadic” as hereditary: insight.jci.org/articles/vie...

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JCI insight @insight.jci.org · 1d

B cell development may occur earlier in life than previously thought.

Shruti Sharma & team report on a conserved intestinal B cell niche in mice and humans, challenging traditional models of lymphopoiesis: insight.jci.org/articles/vie...

Reposted by JCI insight

katioorni.bsky.social @katioorni.bsky.social · 4d

Our latest study, published in @insight.jci.org , shows how high-dose icosapent ethyl (IPE), an ethyl ester of eicosapentaenoic acid (EPA) remodels circulating lipoproteins and reduces cardiovascular risk markers in healthy individuals.

insight.jci.org/articles/vie...

Graphical abstract of the research article

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JCI insight @insight.jci.org · 3d

Previously shared: How are collecting ducts of the kidney formed and maintained?

This issue’s cover features work by Karen I. López-Cayuqueo & team on the role of transcription factor TFAP2A in the architecture of the adult—but not embryonic—renal collecting duct: insight.jci.org/articles/vie...

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JCI insight @insight.jci.org · 4d

Recurrent acute anterior uveitis frequently occurs in axial spondyloarthropathies.

Here, David A. Copland & team identify tissue-resident IL-23-responsive T cells in the eye as orchestrators of ocular inflammation: insight.jci.org/articles/vie...

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Reposted by JCI insight

Martina Lorey @martinalorey.bsky.social · 6d

Check our newest paper on how IPE (EPA-precursor) supplementation rapidly induces lipoprotein remodeling, and its impact on CVD risk markers in normolipidemic individuals:

insight.jci.org/articles/vie...

@katioorni.bsky.social #MedSky #CVD #Atherosclerosis #ScienceSky #Lipoproteins

JCI Insight - Icosapent ethyl–induced lipoprotein remodeling and its impact on cardiovascular disease risk markers in normolipidemic individuals

insight.jci.org

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JCI insight @insight.jci.org · 4d

CLN2 disease is a childhood-onset neurodegenerative lysosomal storage disorder caused by TPP1 deficiency, but little is known about the cellular cause.

Takahashi et al. show GABAergic interneurons contribute to the fatal seizure phenotype in CLN2 disease mice: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 5d

The effects of GLP-1RAs on lung cancer outcomes👇

Sai Yendamuri & team report GLP-1RAs suppress tumor growth selectively in obesity, enhance lung cancer-specific clinical outcomes, and augment immunotherapy efficacy: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 5d

Children treated with proton pump inhibitors for eosinophilic esophagitis often don’t respond

Chakraborty et al. analyzed biopsies from pediatric patients, revealing transcriptional signatures for PPI- responsive & -unresponsive eosinophilic esophagitis: insight.jci.org/articles/vie...

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JCI insight @insight.jci.org · 6d

How are the collecting ducts of the kidney formed and maintained?

This issue’s cover features work by Karen I. López-Cayuqueo & team on the role of transcription factor TFAP2A in the architecture of the adult—but not embryonic—renal collecting duct: insight.jci.org/articles/vie...

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JCI insight @insight.jci.org · 7d

How might air pollution contribute to insulin resistance?

Sanjay Rajagopalan & team demonstrate exposure to PM2.5 air pollution in mice leads to mitochondrial dysfunction in brown fat & metabolic dysfunction through epigenetic regulation: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 8d

NF1 is frequently mutated in glioblastoma, yet therapies targeting this alteration often fall short.

Harish N. Vasudevan & team now show NF1 mutant glioblastomas exhibit prognostic signatures with distinct sensitivity to MEK inhibition: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 9d

ICYMI: Proof-of-concept: A vaccination strategy to prevent coxsackie virus B3–induced development of pancreatic cancer

Pandey et al. vaccinate mice against the common enterovirus CVB3, decreasing infected cells & dramatically reducing abnormal pancreatic areas: insight.jci.org/articles/vie...

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JCI insight @insight.jci.org · 10d

Previously shared: A technical advance in the field of organ transplantation!

@tobias-b-huber.bsky.social & team develop a metabolite-enhanced perfusion solution that improves kidney transplant viability, testing it across various species, including humans: insight.jci.org/articles/vie...

JCI insight @insight.jci.org · 11d

How can we study the effects of radiation on immune cells in #cancer?

Using innovative human pancreatic tumor models, @science-wallet.bsky.social and team reveal photon and particle radiotherapy induce signals—grouped as modules—that attract immune cells: insight.jci.org/articles/vie...

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American Physician Scientists Association @a-p-s-a.bsky.social · 12d

🚨 New publication! 🚨In this perspective published in
@insight.jci.org, previous APSA Presidents and Executive Committee members highlight key APSA milestones in strengthening the physician-scientist community, including 20 years of the joint ASCI/AAP/APSA annual meeting!

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JCI insight @insight.jci.org · 12d

On a FOX hunt in severe autoimmunity

Jonathan S. Maltzman & team explore the functional interactions among FOXP family members in regulatory T cells, revealing loss of Foxp1 & Foxp4 in Tregs from mice causes systemic inflammation and premature lethality: buff.ly/4kzMQe0

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JCI insight @insight.jci.org · 13d

Behind the Scenes: the Khader lab takes a summer outing!

JCI insight @insight.jci.org · 13d

This case series highlights risk factors for infection by a non-tuberculous mycobacterium.

Ananya Gupta @drabhi.bsky.social et al. link GATA2 mutation in the context of immune dysfunction to enhanced susceptibility to M. heamophilum infection in humans: buff.ly/pPIhSlx

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JCI insight @insight.jci.org · 14d

This research article is climbing to the top with views!

Stimulation of skeletal stem cells in the growth plate promotes linear bone growth by Dana Trompet et al.

buff.ly/bvEZnpb

JCI Insight - Stimulation of skeletal stem cells in the growth plate promotes linear bone growth

Research ArticleBone biologyStem cells Open Access | 10.1172/jci.insight.165226

insight.jci.org

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JCI insight @insight.jci.org · 14d

Proof-of-concept: A vaccination strategy to prevent coxsackie virus B3–induced development of pancreatic cancer

Pandey et al. vaccinate mice against the common enterovirus CVB3, decreasing infected cells & dramatically reducing abnormal pancreatic areas: buff.ly/EV0u2mK

JCI insight @insight.jci.org · 15d

A technical advance in the field of organ transplantation!

@tobias-b-huber.bsky.social & team develop a metabolite-enhanced perfusion solution that improves kidney transplant viability, testing it across various species, including humans:
buff.ly/FyKsRiE

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