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Reposted by Fergus O'Farrell

Edinburgh Neuroscience @edinunineuro.bsky.social · Jul 16

📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.

Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠

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Reposted by Fergus O'Farrell

Tara Spires-Jones 🌈🔬 @tspiresjones.bsky.social · Jul 17

Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.

Edinburgh Neuroscience @edinunineuro.bsky.social · Jul 16

📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.

Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠

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Fergus O'Farrell @fergusofarrell.bsky.social · Apr 27

Medium rare. Vanishingly common. Not rare but not not uncommon.

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Fergus O'Farrell @fergusofarrell.bsky.social · Apr 11

My amazing pal Gene Koh strikes again! #InDel #CancerGenomics #MutationalSignatures @naturegenet.bsky.social

Serena Nik-Zainal @serenanikzainal.bsky.social · Apr 10

PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻

A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet

Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)

Tweetorial below!! 👇

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www.nature.com/articles/s41...

A redefined InDel taxonomy provides insights into mutational signatures - Nature Genetics

This paper describes a framework for classifying small insertions and deletions from genomic data and applies it to a large dataset comprising seven tumor types. The analysis highlights new insertion ...

www.nature.com

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Fergus O'Farrell @fergusofarrell.bsky.social · Apr 6

Prescient urban planners installed this lovely sculpture of the Down Jones index in Cambridge 😌.
#stockmarketcrash

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Reposted by Fergus O'Farrell

BDIAP @britishdiviap.bsky.social · Mar 4

Today is the 17th BDIAP Approach to Cut-Up Study Day! The study day provides an opportunity for attendees to learn more about how to tackle some of the complex specimens that they may encounter in their departments.
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation

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Reposted by Fergus O'Farrell

BDIAP @britishdiviap.bsky.social · Mar 3

The 10th BDIAP Molecular Pathology Study Day has started!

#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation #HealthcareProfessionals #StudyDay #BookNow
#pathology #histopathology #pathologyeducation #biomedicalscientist #pathologists

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Reposted by Fergus O'Farrell

Holly Gildea @hollygildea.bsky.social · Feb 21

Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social

Mechanisms of astrocyte aging in reactivity and disease - Molecular Neurodegeneration

Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organis...

molecularneurodegeneration.biomedcentral.com

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Fergus O'Farrell @fergusofarrell.bsky.social · Feb 18

Dr Hunter was sassy 😌😂

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Reposted by Fergus O'Farrell

Baptiste Lacoste @blacoste.bsky.social · Feb 18

Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes

Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke - Nature Neuroscience

Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function ...

doi.org

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Fergus O'Farrell @fergusofarrell.bsky.social · Feb 17

This is how post-mortems should be documented 😉. From: Descriptive catalogue of the pathological series in the Hunterian Museum of the Royal College of Surgeons of England (1966) #PathSky

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Fergus O'Farrell @fergusofarrell.bsky.social · Feb 15

"The drowsy stillness of the afternoon was shattered by what sounded to his strained senses like G.K. Chesterton falling on a sheet of tin." P. G. Wodehouse

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Reposted by Fergus O'Farrell

Katie Sandlin @kmsandlin.bsky.social · Feb 14

Today, along with 2,000 other NIH employees, I had to clear out my office 😭

It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.

Office desk without any personal items or decor

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Reposted by Fergus O'Farrell

Catherine Hall @cathnaledi.bsky.social · Feb 13

@physoc.bsky.social has a starter pack of physiologists. Hooray!! go.bsky.app/2KU1XD6

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Reposted by Fergus O'Farrell

Nature Neuroscience @natneuro.nature.com · Jan 14

A Perspective from @sierralab.bsky.social on #microglia as hunters or gatherers of brain synapses

www.nature.com/articles/s41...

Microglia as hunters or gatherers of brain synapses - Nature Neuroscience

How microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro...

www.nature.com

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Fergus O'Farrell @fergusofarrell.bsky.social · Jan 1

2025 resolution: leave the pit that is Cambridge

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Reposted by Fergus O'Farrell

Samuel Pepys @samuelpepys.bsky.social · Jan 1

Waking out of my sleep on a sudden, I did with my elbow hit my wife a great blow over her face and nose, which waked her with pain, at which I was sorry, and to sleep again.

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Fergus O'Farrell @fergusofarrell.bsky.social · Jan 1

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 13 (ish)

Cancer Ward, Aleksandr Solzhenitsyn

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Fergus O'Farrell @fergusofarrell.bsky.social · Dec 25

My neuroscience Christmas decorations c. 2013

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Fergus O'Farrell @fergusofarrell.bsky.social · Dec 25

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 12

War and Peace, Leo Tolstoy

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Fergus O'Farrell @fergusofarrell.bsky.social · Dec 24

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 11

Vanity Fair, William Makepeace Thackeray

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Fergus O'Farrell @fergusofarrell.bsky.social · Dec 23

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 10

Middlemarch, George Eliot (Mary Ann Evans)

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Fergus O'Farrell @fergusofarrell.bsky.social · Dec 22

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 9

A Manual for Cleaning Women, Lucia Berlin

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Fergus O'Farrell @fergusofarrell.bsky.social · Dec 21

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 8

The Prime of Miss Jean Brodie, Muriel Spark

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Fergus O'Farrell @fergusofarrell.bsky.social · Dec 20

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge

Day 7

The Grapes of Wrath, John Steinbeck

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