Author summary Recent research has shown that the high-fat diet (HFD) may increase the risk of memory problems and conditions like Alzheimer’s disease, but how these diets affect memory formation remains unclear. Our study used fruit flies as a simple model to explore how HFD influences memory. Our findings show that when fruit flies were fed HFD, it specifically impaired their intermediate-term memory (memory lasting several hours) while leaving short-term memory unaffected. We discovered that HFD reduces a crucial cellular cleaning process called autophagy in the brain, which normally helps remove cellular waste and maintain healthy function. When we enhanced this cleaning mechanism in the flies’ brains, the memory issues were reversed under HFD conditions. This study provides new insights into how diet influences memory and may contribute to future research on preventing or treating memory loss associated with aging and neurodegenerative diseases.

"The guy at the epicenter [is] basically starting to do what all ultimate bad actors do in the final inning," Morgan Stanley's Lisa Shalett tells Fortune.

TL;DR Over the past few years, AI has made remarkable progress, but it doesn’t always deliver what professional developers need. One key reason is that most models are trained on public datasets th