Haematophagous organisms are a rich source of salivary anticoagulant polypeptides that exert their activity by blocking the catalytic site and one of two positively charged exosites on the host protea...

Structurally characterized Pr(iv) complexes are limited to four examples because the ligands and reaction conditions capable of stabilizing Pr(iv) remain elusive. Here we identify reaction conditions ...

Hybrid molecule featuring leech, tsetse fly and flea peptide fragments binds thrombin at three sites

Fluorinated arenes are ubiquitous in synthetically and medicinally valuable compounds. Direct fluorination of arene C–H bonds is an attractive disconnection to these targets, but methods are far more ...

Ferroptosis is a promising strategy against apoptosis-resistant tumors, yet traditional iron-induced approaches face safety issues and unsatisfied efficacy within complex tumor microenvironments, high...

The targeted formation of low-symmetry coordination cages represents a significant design challenge but offers the potential to engineer bespoke molecular hosts with precision. In this work, we have c...

Messenger RNA (mRNA) delivery vectors are pivotal in the realm of vaccines and gene therapy. While polymer-based delivery vectors have garnered growing interest owing to their tunable structures and f...

Zeolitic imidazolate framework-8 (ZIF-8), constructed from Zn2+ ions and 2-methylimidazole (mIm) linkers, is widely recognized for its excellent thermal and chemical stability, making it a strong cand...

Atomically dispersed transition metal, nitrogen co-doped carbon (M–N–C) is hailed as the most promising platinum alternative for the oxygen reduction reaction (ORR); however, its practical deployment ...

Developing multifunctional materials with superior mechanical properties, including high hardness and oxidation resistance, remains essential for aerospace, defense, and industrial applications. Machine learning offers a powerful, data-driven pathway for discovering new hard, oxidation-resistant materials for these

Crystallization-driven self-assembly (CDSA) of amphiphilic crystallizable block copolymers represents a powerful tool for constructing precision nanostructures with uniform shapes and dimensions. To date, major efforts have been made towards achieving structural control by employing living-CDSA. Herein, we unravel

Targeting chimeras (TACs), such as PROTACs, LYTACs, AUTACs, and ATTECs, have emerged as promising strategies for selectively degrading proteins, including undruggable targets. These approaches leverage bifunctional molecules or molecular glues to selectively degrade specific proteins, offering new therapeuti

Superhydrophobic coatings, renowned for their remarkable water repellence, have attracted considerable attention for diverse applications, but their practical application is often hindered by insufficient mechanical robustness. Among various strategies proposed to address this limitation, the use of adhesives has e

Amorphous materials with thickness thinned down to the single-layer limit have attracted increasing interest due to their well-defined disorder and emerging unique properties, such as disorder-dominated electronic states, high-density unsaturated coordination, enhanced quantum confinement, etc. These feature

In situ quantitative analysis of electrode surfaces, particularly the identification of active sites and reaction intermediates, is essential for elucidating structure–activity relationships and understanding the mechanisms underlying electrocatalytic reactions. Although conventional spectroscopic techniques are wi

The reversible covalent bond formation that underpins dynamic covalent chemistry (DCC) enables the construction of stimuli-responsive systems and the efficient assembly of complex architectures. While most DCC studies have focused on systems at thermodynamic equilibrium, there is growing interest in systems