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Dr Fabrício Campos @camposvet.bsky.social · 1d

#H5N1 #Influenza #OneHealth #Biosafety

Bhavesh et al., 2025 doi.org/10.1186/s422...

McLeod-Morin et al., 2025 edis.ifas.ufl.edu/publication/...

Smith et al., 2025 doi.org/10.1016/j.pu...
10/10

Highly pathogenic avian influenza H5N1 viral infection in cattle: an emerging threat to global dairying? - Bulletin of the National Research Centre

Official International Journal of the National Research Centre of Egypt

doi.org

Dr Fabrício Campos @camposvet.bsky.social · 1d

Clear and empathetic communication is key to the One Health response. Fighting H5N1 requires listening to those who milk, those who consume, and those who communicate. The next barrier may not be in the lab but in how we talk about the virus. 9/10

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Dr Fabrício Campos @camposvet.bsky.social · 1d

This process builds trust and dialogue between technical teams and those performing the riskiest tasks, highlighting an essential path: integrating science, visual communication, and cultural translation into biosafety strategies. 8/10

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Dr Fabrício Campos @camposvet.bsky.social · 1d

Biosafety depends not only on rules but also on effective communication and local engagement. A recent study showed that adherence to protective measures increases when educational materials are co-produced with farm workers. 7/10

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Dr Fabrício Campos @camposvet.bsky.social · 1d

New variants, such as genotype D1.1, indicate ongoing adaptation to mammals. With no approved vaccines, prevention relies on active surveillance, herd testing, and strict use of personal protective equipment by farm workers. 6/10

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Dr Fabrício Campos @camposvet.bsky.social · 1d

With economic losses estimated between US$ 14 and 164 billion, H5N1 threatens the sustainability of the dairy industry and increases uncertainty in global supply chains. The virus is already circulating across multiple U.S. states. 5/10

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Dr Fabrício Campos @camposvet.bsky.social · 1d

It can cause systemic disease in mice and encephalitis in cats. Pasteurization (72 °C/15 s) and cheese acidification inactivate the virus, although RNA may still be detected. The risk lies in raw milk — pasteurized and inspected products remain safe. 4/10

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Dr Fabrício Campos @camposvet.bsky.social · 1d

In humans, cases have been mild, with conjunctivitis and respiratory symptoms after ocular exposure to droplets of infected milk, not ingestion. Studies show the virus remains viable in refrigerated milk for up to eight weeks. 3/10

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Dr Fabrício Campos @camposvet.bsky.social · 1d

With an unusual tropism for the mammary gland, the virus can spread via fomites such as milking machines, boots, and clothing. The detection of viral RNA in barn air suggests aerosol transmission, and raw milk from infected cows can infect calves. 2/10

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Dr Fabrício Campos @camposvet.bsky.social · 1d

Post 45 — H5N1: Risk Communication and On-Farm Biosafety

The spread of H5N1 to dairy cattle marked a turning point in the panzootic. Clade 2.3.4.4b (genotype B3.13) infected up to 15% of cows on affected U.S. farms, causing fever, mastitis, decreased milk yield, and milk alterations. 1/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

#H5N1 #Influenza #OneHealth #Pandemic #Zoonoses
- Bhadelia et al., 2025. doi.org/10.17226/29273
- Li et al., 2025. doi.org/10.1016/j.ji...
- Nooruzzaman et al., 2025. doi.org/10.1038/s415...
10/10

Diagnostic Tools, Gaps, and Collaborative Pathways in Human H5N1 Detection: Rapid Expert Consultation

Read online, download a free PDF.

doi.org

Dr Fabrício Campos @camposvet.bsky.social · 5d

Strengthening diagnostic capacity and integrating animal, human, and environmental health data is not just preventive — it’s the only way to act before the next mutation enables sustained human transmission. 9/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

These findings stress the need to mitigate zoonotic risks across the food chain, especially after H5N1’s expansion into dairy cattle. The picture is clear: this virus is adapting to new hosts, crossing ecosystems, and testing global surveillance limits. 8/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

Another study showed H5N1 can remain infectious for up to 120 days in raw-milk cheese under certain pH conditions (6.6–5.8). Though ferrets fed contaminated cheese didn’t get infected, the virus stayed stable — a clear risk in unpasteurized dairy products. 7/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

The same mutation, now seen in H5N1 from cattle and humans in the U.S., enhances viral replication and transmissibility in mammals. Qinghai acts as a viral convergence node where strains meet and mix, fueling the rise of variants with pandemic potential. 6/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

Meanwhile, evidence of H5N1 adaptation and persistence grows. In China, researchers detected the PB2-E627K mutation — a marker of mammalian adaptation — in brown-hooded gulls at Qinghai Lake, a key migratory hub. It’s the first such finding in wild birds since 2020. 5/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

These tools must link to real-time genomic databases that track viral evolution and trigger automatic alerts. Preparedness demands not only innovation, but also funding incentives and regulatory flexibility to validate new diagnostic tools during emergencies. 4/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

Most clinical tests only identify influenza A, without distinguishing the subtype — a bottleneck that hinders outbreak control and medical response. Experts call for rapid, scalable, and accessible diagnostics, including point-of-care and home testing platforms. 3/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

A new report warns that, even after 70+ human cases in the U.S., testing remains limited to few labs. 2/10

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Dr Fabrício Campos @camposvet.bsky.social · 5d

Post 44 — H5N1: diagnostics, adaptation, and global surveillance

As the H5N1 virus expands its reach among birds and mammals, the gap between viral spread and global detection capacity continues to grow. 1/10

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Dr Fabrício Campos @camposvet.bsky.social · 8d

Brandt et al., 2025. doi.org/10.1093/clin...
Hernando-Asensio et al., 2025. www.sanidad.gob.es/areas/alerta...
Peyre and Hautefeuille, 2025. doi.org/10.35690/978...
Plaza et al., 2025. Dryad. doi.org/10.5061/drya...
Wang et al., 2025. doi.org/10.1038/s442...
15/15

B-216 Development and Performance Evaluation of a Molecular Reference Material for Influenza H5N1 Strain Screening

AbstractBackground. Influenza A H5N1 is a highly pathogenic avian influenza virus strain that poses a significant threat to global public health due to its

doi.org

Dr Fabrício Campos @camposvet.bsky.social · 8d

H5N1 follows the same path: a global, adaptive virus that depends on these joint measures.

#H5N1 #AvianInfluenza #OneHealth #GlobalHealth #Surveillance #Zoonoses #GlobalChange
14/15

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Dr Fabrício Campos @camposvet.bsky.social · 8d

The control of H7N9 in Asia — through the closure of live animal markets and poultry vaccination — showed that coordinated actions reduce human infections. 13/15

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Dr Fabrício Campos @camposvet.bsky.social · 8d

These findings reinforce the One Health principle: viruses that cross species boundaries can only be contained through integrated surveillance involving humans, animals, and the environment. 12/15

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Dr Fabrício Campos @camposvet.bsky.social · 8d

This advancement helps standardize assays globally and allows early detection of the virus — an essential step to contain future epidemic waves. 11/15

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