Brandon Walters
@brandon.theepilab.ca
50 followers
45 following
8 posts
Professor of Biology at University of Toronto Mississauga. Specializing in Molecular Neuroscience, RNA modifications, and being grumpy! All views expressed are my own.
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Brandon Walters
@brandon.theepilab.ca
· Jun 3
New preprint! In 2014, we showed that histone variants are new regulators of memory and ever since, we wondered if histone H2A.Z contributes to Alzheimer's. Using human brains and 5xFAD mice, we found that it depends on if you're male or female. Summary below. www.biorxiv.org/cgi/content/...
Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients
Alzheimer's disease (AD) is a devastating neurodegenerative disease that disproportionately impacts women, but underlying mechanisms for sex-divergent outcomes are unknown. Here, we show that the hist...
www.biorxiv.org
Reposted by Brandon Walters
Iva Zovkic
@ivazovkic.bsky.social
· Jun 2
Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients
Alzheimer's disease (AD) is a devastating neurodegenerative disease that disproportionately impacts women, but underlying mechanisms for sex-divergent outcomes are unknown. Here, we show that the hist...
www.biorxiv.org
Brandon Walters
@brandon.theepilab.ca
· Mar 5
Brandon Walters
@brandon.theepilab.ca
· Nov 15
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…
www.sciencedirect.com
Brandon Walters
@brandon.theepilab.ca
· Oct 8
Brandon Walters
@brandon.theepilab.ca
· Sep 13
Brandon Walters
@brandon.theepilab.ca
· Aug 26
